RESEARCH ARTICLE


Synthesis, Characterization and Antimicrobial Evaluation of Novel Mannich Bases Containing Pyrazole-5-One Phosphonates



V. E. Rani*, L. K. Ravindranath
Department of Chemistry, S. K. University, Ananthapuramu, A.P, India


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© Rani and Ravindranath; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Chemistry, S. K. University, Ananthapuramu, A.P, India; E-mail: vesther9@gmail.com


Abstract

Background:

Newly synthesised compounds of phosphonates were prepared by condensation of diethylphosphate with imine which undergoes a reaction of mannich bases with pyrazole containing schiffs base. The base was prepared by condensation of aldehyde with primary amine. These newly synthesised derivatives were characterised by spectral analysis.

Objective:

Mannich bases are very important to synthesize wide variety of natural products and pharmaceuticals.

Method:

Thin Layer Chromatography was performed on aluminum sheet of silica gel 60F254, E-Merk, Germany using iodine as visualizing agent. IR Spectra were recorded as KBr pellets on Perkin-Elmer 1000 units, instruments. All 1H and 13C-NMR spectra were recorded on a Varian XL-300 spectrometer operating at 400MHz and 75 MHz. 31P-NMR spectra were recorded on a Varian XL-spectrometer operating at 161.89MHz. The compounds were dissolved in dimethylsulfoxide and Chemical shifts were referenced to Trimethylsilane (1H and 13C-NMR) and 85% phosphoric acid (31P-NMR).

Results:

Some of the novel synthetic compounds of Pyrazole Mannich base-Phosphonates showed great potential in field of medicinal chemistry and good biological activity.

Conclusion:

It can be concluded that this class of compounds certainly holds great potential for the discovery of novel classes of antimicrobial agents.

Keywords: Antibacterial, Antifungal, Phosphonates, Pyrazole-5-one.