RESEARCH ARTICLE
Synthesis, Characterization and Antimicrobial Evaluation of Novel Mannich Bases Containing Pyrazole-5-One Phosphonates
V. E. Rani*, L. K. Ravindranath
Article Information
Identifiers and Pagination:
Year: 2016Volume: 3
First Page: 49
Last Page: 55
Publisher Id: PHARMSCI-3-49
DOI: 10.2174/1874844901603010049
Article History:
Received Date: 3/4/2015Revision Received Date: 5/4/2016
Acceptance Date: 05/04/2016
Electronic publication date: 18/05/2016
Collection year: 2016
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Background:
Newly synthesised compounds of phosphonates were prepared by condensation of diethylphosphate with imine which undergoes a reaction of mannich bases with pyrazole containing schiffs base. The base was prepared by condensation of aldehyde with primary amine. These newly synthesised derivatives were characterised by spectral analysis.
Objective:
Mannich bases are very important to synthesize wide variety of natural products and pharmaceuticals.
Method:
Thin Layer Chromatography was performed on aluminum sheet of silica gel 60F254, E-Merk, Germany using iodine as visualizing agent. IR Spectra were recorded as KBr pellets on Perkin-Elmer 1000 units, instruments. All 1H and 13C-NMR spectra were recorded on a Varian XL-300 spectrometer operating at 400MHz and 75 MHz. 31P-NMR spectra were recorded on a Varian XL-spectrometer operating at 161.89MHz. The compounds were dissolved in dimethylsulfoxide and Chemical shifts were referenced to Trimethylsilane (1H and 13C-NMR) and 85% phosphoric acid (31P-NMR).
Results:
Some of the novel synthetic compounds of Pyrazole Mannich base-Phosphonates showed great potential in field of medicinal chemistry and good biological activity.
Conclusion:
It can be concluded that this class of compounds certainly holds great potential for the discovery of novel classes of antimicrobial agents.
