Preparation and Evaluation of Multi-Particulate System (Pellets) of Prasugrel Hydrochloride

Navjot Kanwar, Rakesh Kumar, V.R. Sinha*
UIPS, Panjab University, Chandigarh 160014, India

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 762
Abstract HTML Views: 402
PDF Downloads: 3
Total Views/Downloads: 1169
Unique Statistics:

Full-Text HTML Views: 428
Abstract HTML Views: 253
PDF Downloads: 3
Total Views/Downloads: 686

© Kanwar and Khan; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the (, which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the UIPS, Panjab University, Chandigarh 160014, India; Tel: +91 172 2534101; Fax: +91 172 2543101; E-mail:


Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the process parameters for the preparation of final batches. Various pellet properties were evaluated like size & shape analysis, flow properties, bulk & tapped density, friability, moisture content, drug content, in vitro release rate and in vivo pharmacodynamic studies. All pellet batches showed a narrow particle size distribution, good sphericity and excellent flow properties. Drug content and moisture content of different pellet batches were found in specified limits. The release kinetics of drug loaded MCC pellets followed Peppas model with Fickian diffusion of prasugrel from the pellets. In vivo pharmacodynamic studies exhibited improved bleeding time in pellet group when compared with the marketed tablet formulation.

Keywords: Carr index, Hausner ratio, MCC pellets, Microwave oven drying, Prasugrel hydrochloride.