Preparation and Evaluation of Multi-Particulate System (Pellets) of Prasugrel Hydrochloride
Navjot Kanwar, Rakesh Kumar, V.R. Sinha*
Identifiers and Pagination:Year: 2015
First Page: 74
Last Page: 80
Publisher Id: PHARMSCI-2-74
Article History:Received Date: 26/12/2014
Revision Received Date: 3/10/2015
Acceptance Date: 27/10/2015
Electronic publication date: 18/12/2015
Collection year: 2015
open-access license: This is an open access article licensed under the terms of the (https://creativecommons.org/licenses/by/4.0/legalcode), which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.
Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the process parameters for the preparation of final batches. Various pellet properties were evaluated like size & shape analysis, flow properties, bulk & tapped density, friability, moisture content, drug content, in vitro release rate and in vivo pharmacodynamic studies. All pellet batches showed a narrow particle size distribution, good sphericity and excellent flow properties. Drug content and moisture content of different pellet batches were found in specified limits. The release kinetics of drug loaded MCC pellets followed Peppas model with Fickian diffusion of prasugrel from the pellets. In vivo pharmacodynamic studies exhibited improved bleeding time in pellet group when compared with the marketed tablet formulation.