Analytical Methods for Determination of Muscle Relax-ant Thiocolchicoside in Pharmaceutical Preparations- A Review

J.K. Rajput, P.H. Patil, S. J. Surana, A. A. Shirkhedkar*
Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule (MS), 425 405 India

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* Address correspondence to this author at the Department of Pharmaceuti-cal Chemistry, R. C. Patel Institute of Pharmaceutical Education and Re-search, Shirpur, Dist. Dhule (MS), 425 405, India; Tel: +91-9823691502; Fax: +91-2563251808; E-mail:


Thiocolchicoside is a centrally acting muscle relaxant and used in combination with many NSAIDs for the treatment of various musculoskeletal disorders. As it is less sedative than other centrally acting muscle relaxants hence frequently prescribed for low back pain (LBP), orthopedic, traumatic and rheumatologic disorders. It is available in market in single component and as multicomponent formulations. Various analytical methods are available for determination of thiocolchico-side in drug substances and formulated products. The present article summarizes more than 100 analytical methods including all types of chromatographic, UV-Visible spectrophotometry and radio immune assays with their percentage of utility for de-termination of thiocolchicoside in biological matrices, bulk material and different pharmaceutical formulations.

Keywords: Analytical methods, thiocolchicoside..